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Top : Colorectal > Colorectal Oncogene

Colorectal Oncogene
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31. Important discovery about colorectal cancer

and colleagues in Australia and Japan have shown that in some cases colorectal cancer can be inherited -- Frequent mutation of an oncogene called BRAF (also mutated in cancer
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http://www.medicalnewstoday.com/medicalnews.php?newsid=20700
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32. Important discovery about second most fatal cancer

Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in the These polyps also show mutation of the oncogene BRAF and DNA methylation
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http://www.eurekalert.org/pub_releases/2005-03/mu-ida030305.php
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33. Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is

methylation in many human tumorsincluding colorectal carcinomas. To study the relevance of Brandt. K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands
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http://cancerres.aacrjournals.org/cgi/content/full/60/9/2368
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34. Linking Tumor-Suppressor Loss and Oncogene Activation

A couple of citation superstars are at it againwith a paper that built a bridge between two well studiedbut hitherto unlinked More than 85 percent of colorectal cancers have a mutation that truncates the adenomatous polyposis coli (APC
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http://www.sciencewatch.com/march-april2000/sw_march-april2000_page8.htm
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35. MACGN Professionals - Prostate Cancer

the Determination of Microsatellite Instability in Colorectal CancerCancer Research5885248-525715 Mutations of the RET Proto-Oncogene in Medullary Carcinoma of the Thyroid
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http://www.macgn.org/p_journals_99.html
Rating: [0.00] Votes: [0] Hits: [0] | Oct 7, 2005


36. MOLECULAR GENETICS FACULTY

Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. Oncogene 22: 6304-6310. 1) expression in human colorectal cancer. Oncogene 243657-3668.
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http://www.aecom.yu.edu/home/molgen/faculty/weber1.html
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37. myDNA.com - News: Important discovery about colon cancer

Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in Canada These polyps also show mutation of the oncogene BRAF and DNA methylation
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http://www.mydna.com/health/colorectal_cancer/resources/news/200503/news_20050304_colon.html
Rating: [0.00] Votes: [0] Hits: [0] | Oct 7, 2005


38. News

Important discovery about colorectal cancer. 3/7/2005 Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroidovaryand melanoma)
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http://www.ccac-accc.ca/news.asp?vatras=3/7/2005&vcod=225
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39. Onkologi - Klinisk Experimentell Forskning

and adjuvant therapy in patients with colorectal cancer. Colorectal cancer is a common malignant such as MLH1MSH2)oncogene (such as rasc-erbB-2)anti-oncogene (such as
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http://www.hu.liu.se/onkologi?node=29960
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40. Patent 6 322 986

The term "colorectal cancer" includes adenocarcinoma and carcinoma of the colon whether in a 706 (1985)Drebin et alOncogene 2: 273-277 (1988)Drebin et alOncogene 2: 387
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http://www.pharmcast.com/Patents/Yr2001/Nov2001/112701/6322986_Colorectal112701.htm
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41. Pathology Update

an early form of colorectal cancer. The study colorectal carcinomas develop from a de novo carcinoma and only 20% to 30% from a preexisting adenoma. They also found p53 oncogene
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http://www.moffitt.usf.edu/pubs/ccj/v4n2/department4_5.html
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42. Penn State Faculty Research Expertise Database (FRED)

of the molecular basis for metastatic disease in colorectal cancer. For the past eight years I have on the Src oncogene and its role in colorectal cancer progression with
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http://fred.hmc.psu.edu/ds/retrieve/fred/investigator/rirby
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43. PreGen Plus - Non-Invasive Colorectal Cancer Screening - Patient Information

Guide to Clinical Use. What is PreGen-Plus? oncogeneand the APC and p53 tumor suppressor genes. These genes are known to be involved in the development of colorectal 15% of sporadic colorectal cancersparticularly those
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http://www.labcorp.com/services/hcp/colorectal_cancer/guide_to_clinical_use.html
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44. Protein called CK2 plays a deadly role in colorectal carcinoma

a deadly role in colorectal carcinoma by blocking the colorectal cancer to investigate the role of CK2 in tumors is now bearing fruit " said Houghtonsenior author of the Oncogene
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http://www.news-medical.net/print_article.asp?id=7942
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45. Proto-Oncogenes and Cancer

The distinction between the terms proto-oncogene and oncogene relates to the activity of the protein gene is one of the most frequently disrupted genes in colorectal carcinomas
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http://web.indstate.edu/thcme/mwking/oncogene.html
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46. References

alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP). Oncogene the adenomatous polyposis coli gene in colorectal tumors. Cancer Res
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http://www.medscape.com/content/2003/00/46/12/461217/461217_ref.html
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47. Requirement of phospholipase D1 activity in H-RasV12-induced transformation -- Buchanan et al. 102 (5): 1638 --

of the Ras oncogene to transform normal oncogeneeventually resulting in the loss of p53 function (26). Because the prevalence of Ras mutations in colorectal
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http://www.pnas.org/cgi/content/full/102/5/1638
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48. Role of the Dependence Receptor DCC in Colorectal Cancer Pathogenesis -- Mehlen and Fearon 22 (16): 3420 -- Journal

alterations in human colorectal and pancreatic tumor dissemination. Oncogene 19:546555 consistently expressed in colorectal cancers and metastases. Oncogene 13:7877951996
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http://www.jco.org/cgi/content/full/22/16/3420
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49. St. Jude Children's Research Hospital - Copyright 2003

A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the body. colorectal cancer to investigate the role of CK2 in tumors is now bearing fruit " said Houghtonsenior author of the Oncogene
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http://www.stjude.org/print/0
Rating: [0.00] Votes: [0] Hits: [0] | Oct 7, 2005


50. The c-kit Tyrosine Kinase Inhibitor STI571 for Colorectal Cancer Therapy -- Attoub et al. 62 (17): 4879 -- Cancer

This Article. Services. PubMed. Advances in Brief. The c-kit Tyrosine Kinase Inhibitor STI571 for Colorectal Cancer Therapy1 c-kit tyrosine kinases. Human colorectal tumors also express the c-kit proto-oncogene. The present study focuses activity of STI571 in human colorectal tumor cells in vitro and in
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http://cancerres.aacrjournals.org/cgi/content/full/62/17/4879
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51. The Sanger Institute: Cancer Genome Project

324. colorectalpancreaticdesmoidhepatoblastomagliomaother CNS. colorectalpancreaticdesmoid sarcoma viral oncogene homolog B1. 673. melanomacolorectalpapillary thyroid
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http://www.sanger.ac.uk/genetics/CGP/Census/missense_mutation.shtml
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52. The Sanger Institute: Cancer Genome Project

v-abl Abelson murine leukemia viral oncogene homolog 1 v-raf murine sarcoma viral oncogene homolog B1. 673. melanomacolorectalpapillary thyroidborderline ovNon small
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http://www.sanger.ac.uk/genetics/CGP/Census/symbol.shtml
Rating: [0.00] Votes: [0] Hits: [0] | Oct 7, 2005


53. Vidyya Medical News Service - Today in Vidyya

Vidyya is a daily Medical News service. The Vidyya Medical News Service provides daily medical newsplus educational materials for patients and professionals. Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in Canada These polyps also show mutation of the oncogene BRAF and DNA methylation
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http://www.vidyya.com/vol7/v7i63_3.htm
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54. VUMC Research; display faculty

that the Ras oncogene is frequently activated in GI malignanciesand particularly colorectal and pancreatic cancers hours after induction of the Ras oncogene. In contrastthe RIE
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http://medschool.mc.vanderbilt.edu/facultydata/php_files/part_dept/show_part.php?id3=731
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55. www.cancer.org/docroot/CRI/content/CRI_2_8_Whats_New_in_Colon_and_Rectum_Cancer_Research_and_Treatment.asp?sitearea=

The Cancer Experience: Colon and Rectum Cancer. What's New in Colon and Rectum Cancer Research and Treatment. Research is always under way in the area of colorectal cancer. to recognize some of the abnormal chemicals in colorectal cancer cells and kill these cells examplethe K-ras oncogene product is altered in many colorectal cancers and researchers
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http://www.cancer.org/docroot/CRI/content/CRI_2_8_Whats_New_in_Colon_and_Rectum_Cancer_Research_and_Treatment.asp?sitearea=
Rating: [0.00] Votes: [0] Hits: [0] | Oct 7, 2005


56. www.cancer.org/docroot/CRI/content/CRI_2_8_Whats_New_in_Colon_and_Rectum_Cancer_Research_and_Treatment.asp?sitearea=CRI&viewmode=print&

Cancer Reference Information. The Cancer Experience: Colon and Rectum Cancer. What's New in Colon and Rectum Cancer Research and Treatment. Research is always under way in the area of colorectal cancer. to recognize some of the abnormal chemicals in colorectal cancer cells and kill these cells examplethe K-ras oncogene product is altered in many colorectal cancers and researchers
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http://www.cancer.org/docroot/CRI/content/CRI_2_8_Whats_New_in_Colon_and_Rectum_Cancer_Research_and_Treatment.asp?sitearea=CRI&viewmode=print&
Rating: [0.00] Votes: [0] Hits: [0] | Oct 7, 2005


57. www.cis.upenn.edu/~mamandel/Annotators/medtree/sanger09-pm09560119.txt

Howeverthe value of K-ras gene determination as a prognostic marker has not been clearly established. of K-ras mutation determines prognosis in colorectal cancer.</p> <p>Cerottini JPCaplin S BACKGROUND: Mutations involving the oncogene K-ras in colorectal cancer may be related
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http://www.cis.upenn.edu/~mamandel/Annotators/medtree/sanger09-pm09560119.txt
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58. www.cis.upenn.edu/~mamandel/Annotators/medtree/sanger17-pm11487539.txt

RESULTS: Ki-ras mutations were detected in 17.2% of the adenomas. p> <p>Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and between Ki-ras mutations in colorectal adenomas and characteristics of both the
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http://www.cis.upenn.edu/~mamandel/Annotators/medtree/sanger17-pm11487539.txt
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59. [Frontiers in Bioscience 2d3438-448September 151997]

Bos: Genetic alterations during colorectal tumor development. N. Engl deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene 112243
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http://www.bioscience.org/1997/v2/d/christ/7.htm
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